الأخبار والتحديثات

ورم بطانة الرحم dMMR المتأخر مع انتشار واسع وتقدم دماغي متكرر — الجمع بين ADC والعلاج المناعي يقلب المسار

51-year-old female with dedifferentiated dMMR endometrial carcinoma (IIIB–IVB). Post-op widespread mets + brain mets with tentorial herniation. First-line chemo-immuno + WBRT achieved PR. Upon intracranial progression, sacituzumab govitecan + pembrolizumab with individualized dosing (5→4 mg/kg) and single-dose bevacizumab for edema control delivered 13+ months of stable disease — a >4× extension over GPA-predicted survival. Commentary by Prof. Wu Ming (PUMCH) & Prof. Sun Min (UPMC).