Métastases généralisées, progressions cérébrales à répétition — l'ADC combinée à l'immunothérapie renverse un cancer de l'endomètre dMMR au stade avancé
51-year-old female with dedifferentiated dMMR endometrial carcinoma (IIIB–IVB). Post-op widespread mets + brain mets with tentorial herniation. First-line chemo-immuno + WBRT achieved PR. Upon intracranial progression, sacituzumab govitecan + pembrolizumab with individualized dosing (5→4 mg/kg) and single-dose bevacizumab for edema control delivered 13+ months of stable disease — a >4× extension over GPA-predicted survival. Commentary by Prof. Wu Ming (PUMCH) & Prof. Sun Min (UPMC).
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